Title: Efficacy of Antibacterial Prophylaxis for Preventing Urinary Tract Infections in Renal Transplant Recipients. Background: The increased incidence of urinary tract infections (UTIs) following organ transplantation necessitates the use of antibacterial prophylaxis. The goal of this review is to describe observational studies concerning the use of antibacterial prophylaxis to prevent UTIs in renal transplant recipient (RTRs). Methods and Findings: Materials were gathered through a structured search of the databases available at the King Saud bin Abdulaziz University for Health Sciences on-line library for articles published between 2007 and 2013. However, due to the scarcity of prospective trials in this topic during this period, this review will be comprehensive rather than systematic. The increased recurrent UTIs in RTRs was associated with immunosuppressive therapy, which necessitates the use of antibacterial prophylaxis to reduce during the first year post-transplantation. However, the efficacy and optimal duration of antibacterial prophylaxis for UTIs remains debatable. Conclusions: Although many studies have agreed on the importance of routine antibacterial therapy, UTI prevalence in RTRs is high. Reducing infection complications may be accomplished by properly choosing of immunosuppressants and antibacterials to achieve a correct balance. However, there was no sufficient evidence to confirm the potential efficacy of antibacterial prophylaxis, hence; more research is needed to further delineate the consequences of using antibacterials in RTRs.
from Archives of Clinical Microbiology http://ift.tt/1rO2O1o